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The fact that hydrochlorothiazide causes weight loss shouldn’t be very surprising given that it functions as a diuretic – causing the body to excrete sodium and water stores. Average weight loss: 1.01 lbs. to 14.77 lbs. Monotherapy: 2.31 lbs. to 6.92 lbs. Polytherapy: 1.01 lbs. to 14.77 lbs.
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